Among my main recent assignments requires characterizing the effect of lack of Dot1l and H3K79 methylation on standard hematopoetic stem cells. I had been recently involved in delineating the consequences of lack of H3K79 around the generation of iPS cells, and we were being capable of display that loss of H3K79 methylation facilitated (probable PRC2 mediated) repression of differentiation associated expression plans that signify a barrier to reprogramming. I've preliminary info suggesting the same position for Dot1l in hematopoietic progress.
People with eosinophilic (EoE) exhibit distinguished basal cell hyperplasia along with eosinophilic inflammation of your esophagus. These abnormalities are caused, partially, by defects in alerts managing cell fate willpower within the esophageal basal cell and stem cell hierarchies effecting both of those stratification and terminal differentiation.
Rural Colorado doctors can be the only real supply of remedy For a lot of miles for opioid addicts who will often be Determined for assist.
People who inconsistently perform at night may encounter blood sugar irregularities bringing about diabetic issues.
The Herson laboratory investigates the acute and very long-term sequelae of acquired Mind damage. The laboratory uses experimental styles of ischemic stroke, cardiac arrest/CPR, and traumatic Mind injury to evaluate histological and purposeful outcomes following injuries.
stem cell self-renewal, proliferation and differentiation. We are producing novel methods to enhance bone marrow stem cell transplantation, purple blood cell production in vitro, and likely lengthen our approach to other adult somatic stem cell sources.
Educating hairdressers in melanoma detection could help you save life of customers with hard-to-place skin most cancers, a study by CU researchers says.
Our lab is serious about knowledge how article-transcriptional Handle contributes browse around here to reprogramming and pluripotency working with human induced pluripotent stem cells like a design.
A CU Down syndrome researcher describes The latest discoveries associated with Down syndrome and cancer, Alzheimer's along with other conditions.
My target is definitely the fetal origins of being overweight and diabetes in mouse, monkey, and man; the transcription Consider the regulation of metabolism.
A CU analyze will Examine the pain relief efficacy of vaporized cannabis and an opioid painkiller for clients with chronic back and neck ache.
Ultramarathoners threat acute kidney injury should they take the painkiller ibuprofen, researchers from CU along with other institutions say.
1. Comprehending molecular mechanisms of cardiac improvement and ailment in mammals. We are researching mechanisms of cardiac enhancement in mammals applying a number of methods.
We are centered on knowledge the mechanisms of your PI3K/PTEN/AKT signaling pathway in routine maintenance of tentative esophagus, oral, and skin stem cells of their tissue homeostasis, with center on the roles in the tentative stem cells in advancement of squamous cell carcinoma in esophagus, oral cavity, and pores and skin.